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<t>ER</t> and PR expression in the MnPP rat and in human cancer-adjacent tissue. (A and B) Representative IHC images depict ERα expression in PND120 mammary glands from control and MnPP female rats, respectfully. (C) ERα expression in human normal breast epithelium and (D) tissue adjacent to ductal carcinoma in situ (DCIS). PR+ expression in control (E) and MnPP rat mammary glands at PND 120 (F). PR+ expression in normal breast epithelium (G) and epithelial tissue adjacent to <t>human</t> <t>invasive</t> lobular carcinoma (panel H). Images of ERα and PR protein expression patterns in human breast tissue were provided by The Human Protein Atlas (available at http://www.proteinatlas.org ) . Scale bar = 0.01 mm. Erα, estrogen receptor alpha; IHC, immunohistochemistry; MnPP, manganese-induced precocious puberty; PID, patient ID; PR, progesterone receptor.
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<t>ER</t> and PR expression in the MnPP rat and in human cancer-adjacent tissue. (A and B) Representative IHC images depict ERα expression in PND120 mammary glands from control and MnPP female rats, respectfully. (C) ERα expression in human normal breast epithelium and (D) tissue adjacent to ductal carcinoma in situ (DCIS). PR+ expression in control (E) and MnPP rat mammary glands at PND 120 (F). PR+ expression in normal breast epithelium (G) and epithelial tissue adjacent to <t>human</t> <t>invasive</t> lobular carcinoma (panel H). Images of ERα and PR protein expression patterns in human breast tissue were provided by The Human Protein Atlas (available at http://www.proteinatlas.org ) . Scale bar = 0.01 mm. Erα, estrogen receptor alpha; IHC, immunohistochemistry; MnPP, manganese-induced precocious puberty; PID, patient ID; PR, progesterone receptor.
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ER and PR expression in the MnPP rat and in human cancer-adjacent tissue. (A and B) Representative IHC images depict ERα expression in PND120 mammary glands from control and MnPP female rats, respectfully. (C) ERα expression in human normal breast epithelium and (D) tissue adjacent to ductal carcinoma in situ (DCIS). PR+ expression in control (E) and MnPP rat mammary glands at PND 120 (F). PR+ expression in normal breast epithelium (G) and epithelial tissue adjacent to human invasive lobular carcinoma (panel H). Images of ERα and PR protein expression patterns in human breast tissue were provided by The Human Protein Atlas (available at http://www.proteinatlas.org ) . Scale bar = 0.01 mm. Erα, estrogen receptor alpha; IHC, immunohistochemistry; MnPP, manganese-induced precocious puberty; PID, patient ID; PR, progesterone receptor.

Journal: Endocrinology

Article Title: Manganese-induced Precocious Puberty Alters Mammary Epithelial Cell Proliferation in Female Rats

doi: 10.1210/endocr/bqaf052

Figure Lengend Snippet: ER and PR expression in the MnPP rat and in human cancer-adjacent tissue. (A and B) Representative IHC images depict ERα expression in PND120 mammary glands from control and MnPP female rats, respectfully. (C) ERα expression in human normal breast epithelium and (D) tissue adjacent to ductal carcinoma in situ (DCIS). PR+ expression in control (E) and MnPP rat mammary glands at PND 120 (F). PR+ expression in normal breast epithelium (G) and epithelial tissue adjacent to human invasive lobular carcinoma (panel H). Images of ERα and PR protein expression patterns in human breast tissue were provided by The Human Protein Atlas (available at http://www.proteinatlas.org ) . Scale bar = 0.01 mm. Erα, estrogen receptor alpha; IHC, immunohistochemistry; MnPP, manganese-induced precocious puberty; PID, patient ID; PR, progesterone receptor.

Article Snippet: Images of ERα and PR protein expression patterns adjacent to human invasive lobular breast carcinoma and ductal carcinoma in situ were provided by The Human Protein Atlas (available at http://www.proteinatlas.org ) ( ).

Techniques: Expressing, Control, In Situ, Immunohistochemistry